CHTN Publications

Collaborative CHTN Efforts

The Cooperative Human Tissue Network of the National Cancer Institute: Supporting Cancer Research for 35 Years.
McCall SJ, Lubensky IA, Moskaluk CA, Parwani A, Radin K, Ramirez NC, Von Menchhofen Z, Washington MK, LiVolsi VA. Mol Cancer Ther. 2023 Oct 2;22(10):1144-1153. doi: 10.1158/1535-7163.MCT-22-0714. PMID: 37523711; PMCID: PMC10626893.

The effects of frozen tissue storage conditions on the integrity of RNA and protein.
Auer H, Mobley JA, Ayers LW, Bowen J, Chuaqui RF, Johnson LA, Livolsi VA, Lubensky IA, McGarvey D, Monovich LC, Moskaluk CA, Rumpel CA, Sexton KC, Washington MK, Wiles KR, Grizzle WE, Ramirez NC. Biotech Histochem. 2014 Oct;89(7):518-28. doi: 10.3109/10520295.2014.904927. Epub 2014 May 6. PMID: 24799092; PMCID: PMC4213858.

Eastern Division Publications

Lessons Learned During Three Decades of Operations of Two Prospective Bioresources.
Grizzle W, Sexton K, McGarvey, D, von Menchhofen Z, LiVolsi, VA. Biopreserv Biobank. 2018. 16:6 483-492. DOI: 10.1089/bio.2018.0073 PMID: 304578779; PMCID: PMC6308275.

Protein Extraction from Methanol-Fixed Paraffin-Embedded Tissue Blocks: A new possibility using cell blocks.
Kokkat TJ, McGarvey D, Patel MS, Tieniber AD, Livolsi VA, Baloch ZW: Cytojournal. 2013. 10:23. DOI: 10.4103/1742-6413.122299 PMID: 24403950. PMC ID:PMC3869970

Archived Formalin-Fixed Paraffin-Embedded (FFPE) Blocks: A valuable underexploited resource for extraction of DNA, RNA, and protein.
Kokkat TJ, Patel MS, McGarvey D, LiVolsi VA, Baloch ZW: Biopreserv Biobank. 2013. 11:101-106. DOI: 10.1089/bio.2012.0052 PMID: 24845430. PMC ID: PMC4077003

Effect of Thaw Temperature in Reducing Enzyme Activity in Human Thyroid Tissue.
Kokkat TJ, McGarvey D, Lovecchio L, and LiVolsi V. Biopreservation and Biobanking, 9(4): 349-354. (2011). DOI: 10.1089/bio.2011.0026 PMID: 24836631

Midwestern Division Publications

Surgical Specimen Dissection and Tissue Procurement Manual, Version 1.0
Ayers LW, Nohle DG. Columbus, Ohio, The Ohio State University, 8/12/2020. http://hdl.handle.net/1811/91999

Digital whole slide tissue images enriched by morphometrics provide region of interest (ROI) for selected technical procedures.
Parwani AV, Mandt RL, Nohle DG, Kellough DA, Ayers LW. International Society for Biological and Environmental Repositories (ISBER) 2020 Educational Program Series, Jun-Oct, 2020. (Poster ITO-02)

Acceptable Weight Ranges for Research Tissue Procurement and Biorepositories, 2015-2017.
Nohle DG, Mandt RL, Couce ME, Parwani AV, Ayers LW. Biopreserv Biobank. 2018 Dec;16(6):463-466. doi: 10.1089/bio.2018.0068. Epub 2018 Oct 31. PMID: 30379574

Mast Cell Activation and KSHV Infection in Kaposi Sarcoma.
Ayers LW, Barbachano-Guerrero A, McAllister SC, Ritchie JA, Asiago-Reddy E, Bartlett LC, Cesarman E, Wang D, Rochford R, Martin JN, King CA. Clin Cancer Res. 2018 Oct 15;24(20):5085-5097. doi: 10.1158/1078-0432.CCR-18-0873. Epub 2018 Jul 3. PMID: 30084838

Southern Division Publications

Precision Pathology as Part of Precision Medicine: Are We Optimizing Patients' Interests in Prioritizing Use of Limited Tissue Samples?
McCall SJ, Dry SM. JCO Precis Oncol. 2019 Dec;3:1-6. doi: 10.1200/PO.18.00238. PMID: 35100673.

Western Division Presentations

• An End-to-End Donor Repository System in an Academic Environment, Kerry Wiles, Kay Washington, M.D. 6^thAnnual Leaders in Biobanking Congress 2014, Seattle, WA
• Cooperative Human TissueNetwork, XY Congress 2014, San Diego, CA
• • Transforming Business Operations of an Academic Biorepository through the Utilization of Measurable KPIsKiley Wease, Nicole Bollinger, Kerry Wiles, Mary Kay Washington ISBER 2014 Annual Meeting, Orlando, FL
  • Retrospective Analysis of Reported Errors for Development of Key Performance IndicatorsErik Brooks, Kiley Wease, Ying Jin, Kerry Wiles, Mary Kay Washington M.D., PhD. Vanderbilt University Medical Center
  • Configuring and Implementing an Error Reporting Feature in a Donor Repository Procurement ApplicationErik Brooks, Kiley Wease, Matt Clement, Ying Jin, Kerry Wiles, Mary Kay Washington MD PhD, Vanderbilt University Medical Center
  • Lean Six Sigma Implementation for the Advancement and Innovation of Bio-Repository OperationsKerry Wiles, Bojana Zivak, Emma Judd, Mary Kay Washington MD, PhD. Vanderbilt University Medical Center ISBER 2012 Annual Meeting, Syndey, Australia

Western Division Poster Presentations at the 2011 European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB) Conference, Marseille, France include the following:

• Lean Six Sigma Implementation for the Advancement and Innovation of Bio-Repository Operations
• Integrating Zoho Customer Relationship Management with Bio-Repositories and Prospective Collection Services
• • Video Procurement: An Essential Educational Tool for Obtaining Quality Research Specimens
  • Reducing Complexity and Increasing Flexibility of Biorepository Systems by Utilizing Web Services

CHTN Investigator Publications Worth Mentioning

The CHTN provided human biospecimens to a study that identified an active transoendothelial pathway into solid tumors. The design of the study incorporated several different approaches to dissect mechanisms that occur in a small subcellular membrane component and that is susceptible to rapid disorganization as cells are dissociated or lose viability. The authors of the publication below note the demonstrated mechanism underlying transvascular pumping by caveolae can be targeted to greatly enhance tumor penetration. This provides new opportunities for the study, interrogation, manipulation and treatment of specific tissues and cells in vivo. The CHTN provided tissues from normal and solid tumors (brain, breast, kidney, liver and prostate cancer).

• In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors.Oh. P et al, Nature Medicine 20:1062-1068, 2014